Outcome of Glycine (1.5%) and 5% Dextrose in Aqua as Irrigation Fluids During Transurethral Resection of Prostate Gland (TURP) Operation- A Prospective Study

Abstract

Background: Transurethral resection of the prostate (TURP) is a common surgical procedure for benign prostatic hyperplasia (BPH). The choice of irrigation fluid during TURP plays a critical role in minimizing complications. Objective: This study aimed to evaluate the efficacy and safety of glycine (1.5%) and 5% dextrose in aqua as irrigation fluids during TURP and to compare their effects on postoperative outcomes. Methods: A prospective multicenter study was conducted from January 2021 to June 2023 at the Department of Urology, Naogaon Medical College, Naogaon, Bangladesh. The study sample consisted of 212 patients undergoing TURP. Patients were randomly assigned to receive either glycine (1.5%) or 5% dextrose in aqua as irrigation fluids. Postoperative outcomes, including complications such as hyponatremia, fluid retention, and recovery time, were recorded. Statistical analysis included t-tests, standard deviation, and p-values to compare the two groups. Results: The glycine group (n=106) showed a 17% incidence of postoperative hyponatremia, compared to 8% in the dextrose group (n=106). The mean recovery time was significantly shorter in the dextrose group (mean = 3.2 ± 0.8 days) compared to the glycine group (mean = 4.1 ± 1.2 days), with a p-value of 0.03. Fluid retention was observed in 13% of the glycine group compared to 6% in the dextrose group (p = 0.02). The standard deviation for fluid retention in the glycine group was 0.22, and in the dextrose group, it was 0.15. Conclusion: 5% dextrose irrigation fluid demonstrated lower complication rates and a faster recovery time compared to glycine, suggesting its potential as a safer alternative during TURP.