Effectiveness of linezolid over traditional antibiotics in osteomyelitis in adults: a review

Abstract

Osteomyelitis is rare but complicated and challenging disease, mainly caused by staphylococcus aureus. Although bone is normally resistant to bacterial colonization, some events such as trauma, surgery may disrupt bony integrity and lead to bone infection. Appropriately designed antibiotic regimens are critical to manage the all stages of osteomyelitis. Methicillin, Vancomycin, Fluoroquinolone, clindamycin and so many antibiotics are used. Recently, several newer agents with good activity against causative organisms have been introduced include linezolid, daptomycin, tigecycline, telavancin and ceftaroline. Their roles in the treatment of acute and chronic osteomyelitis are still being evaluated. The best studied of these is linezolid, a bacteriostatic antibiotic. The comparative role of linezolid and other antibiotics in osteomyelitis are thoroughly evaluated in this review article.