Effect of leaf and Seed Extract of Tamarindus indica on liver weight of Rats toxicated with paracetamol: A comparative study

Abstract

Background: Tamarindus indica, known as tentul or imli having therapeutic interest in various liver aliments caused by viruses, hepatotoxic agents. Objective: To compare the effect of ethanolic extract of leaf and seed of Tamarindus indica on liver weight when liver is toxicated with paracetamol. Methods: A total of twenty-four Long Evan’s rats were collected and divided into four groups. Each group having six rats (n=6). Control group received normal diet ad libitum, only paracetamol group received paracetamol (1500 mg/kg) for 12 days and rest two groups received paracetamol (1500 mg/kg) along with ethanolic extract of seed of Tamarindus indica (1250 mg/kg) and leaf extract of Tamarind (1250mg/kg) for 12 days respectively. On 13th day, all rats were sacrificed. Then livers were collected and weighed by an electronic balance. Results: In this study, the mean (±SD) liver weight was 4.08±0.23 in control group, 6.27±0.68 in only paracetamol treated group, 5.22±0.72 and 5.10±0.78 in paracetamol along with seed extract of Tamarindus indica and leaf extract of Tamarind treated group respectively. Conclusion: The present study showed that mean (±SD) weight of liver increased with paracetamol and decreased with seed extract and leaf extract of Tamarindus indica.