Effect of Vitamin A on Lung Function Test in patient with Chronic Bronchial Asthma

Abstract

Background: Decreased antioxidant levels in the lungs is a feature of chronic bronchial asthma. Anti-oxidant therapy positively correlates with lung function in asthmatic patients. Objective: Decreased antioxidant levels in the lungs is a feature of chronic bronchial asthma. Anti-oxidant therapy positively correlates with lung function in asthmatic patients. Methods: This was a randomized controlled trial carried out in the department of physiology. Rajshahi Medical College, Rajshahi. Adult patients suffering from chronic bronchial asthma were the reference population. Sixty experimental subjects aged 20 to 45years were selected from the Asthma center of Rajshahi Medical College Hospital by necessary inclusion and exclusion criteria. They were divided into two equal groups, study and control by randomization. Pulmonary function parameters such as FVC, FEVI, FEV1/FVC% and PEFR were measured before and three months after supplementation of vitamin A in study subjects and placebo in controls. Paired t-test was applied to observe the difference of lung function parameters between pre and post intervention of the two groups. Results: The mean FVC, FEVI, FEV1/FVC% and PEFR following vitamin A were not changed significantly than the pre supplementation values in patients with chronic bronchial asthma. Conclusion: No significant improvement of pulmonary functions occur after supplementation of vitamin A in chronic bronchial asthma patients.