Number of parietal cell in the gastric gland of gastric mucosa (body) and its relationship with different age group

Abstract

Background: The stomach is the most dilated part of the alimentary tract. It is concerned with a number of diseases like gastritis, peptic ulcer along with its complications like perforation, haemorrhage, gastric outlet obstruction and cancer. In many of this disorder, the treatment procedures include surgical interventions of stomach. A massive knowledge of the perfect histomorphology of stomach carries great importance in the medical and surgical treatment of various stomach-related diseases. The most conspicuous cells of the gastric mucosa are the parietal cells. These are the source of hydrochloric acid and intrinsic factor of gastric juice. Objective: To find out the number of parietal cell mass of the gastric gland in the gastric mucosa of the stomach and its association with age. Methods: This descriptive type of study was conducted in the department of Anatomy, Sir Salimullah Medical College (SSMC), Dhaka from July 2005 to June 2006. Sixty (60) human postmortem stomach were included in this study, age ranging from 0 to70 years. The samples were collected from apparently fresh unclaimed dead bodies within 24 to36 hours of death before showing any signs of decomposition from the morgue of Sir Salimullah Medical College (SSMC) and Dhaka Medical College (DMC), Dhaka. The collected samples were divided into three (3) different age groups: A 0-14years, B-15-22 years and C-23 years and above. Unpaired "t" test was applied to test the differences of mean parietal cell among the different age groups. Results: The mean (±SD) number of parietal cells in group A (0-14 years), B (15-22 years) and C (23 years and above) were 1355.76+52.84, 1420.29±48.32 and 1426.08±114.48 cells/mm² respectively. The mean numbers of parietal cell increased with age but the differences were not significant (P>0.05, 0.10 and >0.50). Conclusion: The number of parietal cells showed significant positive correlation with age but had no significant difference among different age groups.